For four thousand years, the size and vitality of cities, economies, and empires were heavily determined by infection. Striking humanity in waves, the cycle of plagues set the tempo of civilizational growth and decline, since common response to the threat was exclusion—quarantining the sick or keeping them out. But the unprecedented hygiene and medical revolutions of the past two centuries have allowed humanity to free itself from the hold of epidemic cycles—resulting in an urbanized, globalized, and unimaginably wealthy world.
Dispelling many myths and misconceptions about medicine during the Middle Ages, Aberth shows that plague doctors formulated a unique and far-reaching response as they began to treat plague as a poison, a conception that had far-reaching implications, both in terms of medical treatment and social and cultural responses to the disease in society as a whole.
Set in 14th century Aquitaine, France during the Hundred Years' War, the game focuses on the plight of Amicia de Rune and her ill brother Hugo as they flee from soldiers of the French Inquisition and from hordes of rats that are spreading the black plague.